Transplantable pancreatic carcinoma of the rat

J. K. Reddy*, M. S. Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Pancreatic carcinoma, which developed in a male Fischer 344 ratfed 0.1 percent nafenopin for 20 months, is being successfully transplanted into weanling rats. The tumor cells contain variable numbers of zymogen granules, and the endoplasmic reticulum and the Golgi apparatus appear prominent. This transplantable tumor, which displays substantial amylase and lipase activity, should serve as a useful model system for immuno- and chemotherapeutic experiments, as well as for the study ofsynthesis, storage, and release of zymogen proteins in neoplastic cells.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalScience
Volume198
Issue number4312
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • General

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