TY - JOUR
T1 - Transplantable pancreatic carcinoma of the rat
AU - Reddy, J. K.
AU - Rao, M. S.
PY - 1977
Y1 - 1977
N2 - Pancreatic carcinoma, which developed in a male Fischer 344 ratfed 0.1 percent nafenopin for 20 months, is being successfully transplanted into weanling rats. The tumor cells contain variable numbers of zymogen granules, and the endoplasmic reticulum and the Golgi apparatus appear prominent. This transplantable tumor, which displays substantial amylase and lipase activity, should serve as a useful model system for immuno- and chemotherapeutic experiments, as well as for the study ofsynthesis, storage, and release of zymogen proteins in neoplastic cells.
AB - Pancreatic carcinoma, which developed in a male Fischer 344 ratfed 0.1 percent nafenopin for 20 months, is being successfully transplanted into weanling rats. The tumor cells contain variable numbers of zymogen granules, and the endoplasmic reticulum and the Golgi apparatus appear prominent. This transplantable tumor, which displays substantial amylase and lipase activity, should serve as a useful model system for immuno- and chemotherapeutic experiments, as well as for the study ofsynthesis, storage, and release of zymogen proteins in neoplastic cells.
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U2 - 10.1126/science.897688
DO - 10.1126/science.897688
M3 - Article
C2 - 897688
AN - SCOPUS:0017649296
SN - 0036-8075
VL - 198
SP - 78
EP - 80
JO - Science
JF - Science
IS - 4312
ER -