Abstract
A patient with acute mixed lineage leukemia had marked marrow fibrosis at presentation. The fibrosis persisted despite achievement of complete remission. Because the marrow was inaspirable, granulocyte-monocyte colony-stimulating factor (GM-CSF) was used to mobilize stem cells into the peripheral blood which were used for autologous transplantation. Myeloid engraftment was rapid. The extent of the fibrosis decreased after transplantation. GM-CSF-mobilized peripheral blood stem cells may be used for autologous transplantation in patients with fibrotic marrows who are not candidates for allografting.
Original language | English (US) |
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Pages (from-to) | 157-158 |
Number of pages | 2 |
Journal | Leukemia and Lymphoma |
Volume | 11 |
Issue number | 1-2 |
DOIs | |
State | Published - Jan 1 1993 |
Keywords
- Acute leukemia
- Autologous blood stem
- Cell transplantation
- GM-CSF myelofibrosis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research