Transplantation of autologous peripheral blood stem cells mobilized using GM-CSF for acute leukemia with myelofibrosis

J. Mehta*, R. L. Powles, V. Shepherd, M. Dainton, J. Treleaven

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A patient with acute mixed lineage leukemia had marked marrow fibrosis at presentation. The fibrosis persisted despite achievement of complete remission. Because the marrow was inaspirable, granulocyte-monocyte colony-stimulating factor (GM-CSF) was used to mobilize stem cells into the peripheral blood which were used for autologous transplantation. Myeloid engraftment was rapid. The extent of the fibrosis decreased after transplantation. GM-CSF-mobilized peripheral blood stem cells may be used for autologous transplantation in patients with fibrotic marrows who are not candidates for allografting.

Original languageEnglish (US)
Pages (from-to)157-158
Number of pages2
JournalLeukemia and Lymphoma
Volume11
Issue number1-2
DOIs
StatePublished - Jan 1 1993

Keywords

  • Acute leukemia
  • Autologous blood stem
  • Cell transplantation
  • GM-CSF myelofibrosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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