Transport and localization of the DEG/ENaC ion channel BNaC1α to peripheral mechanosensory terminals of dorsal root ganglia neurons

Jaime García-Añoveros*, Tarek A. Samad, Ljiljana Uvela-Jelaska, Clifford J. Woolf, David P. Corey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

197 Scopus citations

Abstract

Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the BNaC1α isoform is expressed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception) and few small nociceptor neurons (which include high-threshold mechanoreceptors). BNaC1α is transported from DRG cell bodies to sensory terminals in the periphery, but not to the spinal cord, and is located specifically at specialized cutaneous mechanosensory terminals, including Meissner, Merkel, penicillate, reticular, lanceolate, and hair follicle palisades as well as some intraepidermal and free myelinated nerve endings, Accordingly, BNaC1α channels might participate in the transduction of touch and painful mechanical stimuli.

Original languageEnglish (US)
Pages (from-to)2678-2686
Number of pages9
JournalJournal of Neuroscience
Volume21
Issue number8
DOIs
StatePublished - Apr 15 2001

Keywords

  • DEG/ENaC channels
  • Degenerin
  • Dorsal root ganglion
  • Mechanosensory
  • Mechanotransduction
  • Nociception
  • Touch
  • Unidirectional transport

ASJC Scopus subject areas

  • Neuroscience(all)

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