Transport pathways of macromolecules between the nucleus and the cytoplasm

Stephen A. Adam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Transport between the nucleus and cytoplasm involves both stationary components and mobile factors acting in concert to move macromolecules through the nuclear pore complex. Multiple transport pathways requiring both unique and shared components have been identified. In the past 18 months, new findings have shed light on the nature of some of the mobile components of these pathways. New receptor-cargo pairs for both import and export pathways have been identified extending the breadth of known transport pathways. Surprising findings on the role of Ran and energy in transport have changed our way of thinking about the mechanism of movement through the nuclear pore.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume11
Issue number3
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Cell Biology

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