Transversus abdominis plane infiltration and quality of recovery after laparoscopic hysterectomy: A randomized controlled trial

Gildasio S. De Oliveira*, Magdy P. Milad, Paul Fitzgerald, Rodd Rahmani, Robert J. McCarthy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Objective: To examine the effect of a preoperative transversus abdominis plane infiltration on postoperative quality of recovery and analgesia in patients undergoing laparoscopic hysterectomy. Methods: The study was a randomized, double-blinded, placebo-controlled trial. Seventy-five healthy women were randomized to receive a preoperative infiltration with 0.5% ropivacaine, 0.25% ropivacaine, or saline. Postoperative quality of recovery score (QoR-40), pain, and opioid consumption were assessed up to 24 hours after the surgical procedure. Data were analyzed using Kruskal-Wallis test. Post hoc pair-wise comparisons were made using Dunn test. P<.05 was required to reject the null hypothesis. Results: Sixty-six patients completed the study. PatientsÊ baseline characteristics and surgical factors were not different between groups. The ropivacaine group experienced a better quality recovery and less postoperative pain than the saline group. The median difference (99.2% confidence interval) in global recovery scores at 24 hours after surgery was 28 (QoR score 4-39, P=.001) for ropivacaine 0.5% and 28 (QoR score 10-43, P<.001) for ropivacaine 0.25% compared with saline, respectively. The 0.5% ropivacaine group also had less pain, lower opioid consumption, and faster postanesthesia care unit discharge than the saline group. Linear regression demonstrated an inverse relationship between opioid consumption and global quality of recovery at 24 hours (P<.001). Conclusion: The transversus abdominis plane infiltration improves quality of recovery. There was an inverse linear relationship between postoperative opioid consumption and quality of recovery. Clinical Trial Registration:, www.clinicaltrials. gov, NCT01074229.

Original languageEnglish (US)
Pages (from-to)1230-1237
Number of pages8
JournalObstetrics and gynecology
Issue number6
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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