Trastuzumab in primary inflammatory breast cancer (IBC): High pathological response rates and improved outcome

Shaheenah Dawood, Yun Gong, Kristine Broglio, Thomas A. Buchholz, Wendy Woodward, Anthony Lucci, Vicente Valero, Ana M. Gonzalez-Angulo, Gabriel N. Hortobagyi, Massimo Cristofanilli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Inflammatory breast cancer (IBC) represents a rare but aggressive and lethal form of locally advanced breast cancer (LABC) and frequently with HER-2 neu overexpressed or amplified. We retrospectively identified 16 newly diagnosed HER-2 /neu-positive IBC patients who were treated with preoperative trastuzumab. We determined the pathological complete response rate (pCR) when trastuzumab was added to preoperative chemotherapy in patients with HER2/neupositive IBC. Furthermore, we assessed the expression of CXCR4 in metastatic recurrence sites. Ten patients (62.5%) achieved a pCR. Six patients (37.5%) achieved a partial response. Median follow-up of all patients was 24.2 months. Four (25%) patients have experienced a progression, of which three were in the brain. Two-year progression-free survival was 59.4% (95% CI 35-100). High expression of CXCR4 was detected in the brain metastases. We conclude that in spite of high pCR rates among women with HER-2 /neu-positive IBC treated with neoadjuvant trastuzumab-based regimens the outcome remains dismal and brain recurrences are frequent. CXCR4 may represent a novel therapeutic target.

Original languageEnglish (US)
Pages (from-to)529-532
Number of pages4
JournalBreast Journal
Volume16
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • CXCR4
  • Inflammatory breast cancer
  • Trastuzumab

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

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