Traumatic brain injury activation of the adult subventricular zone neurogenic niche

Eun Hyuk Chang, Istvan Adorjan, Mayara V. Mundim, Bin Sun, Maria L.V. Dizon, Francis G. Szele*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.

Original languageEnglish (US)
Article number332
JournalFrontiers in Neuroscience
Issue numberAUG
StatePublished - Aug 2 2016


  • Adult neurogenesis
  • Proliferation
  • Regeneration
  • Stem cells
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Neuroscience(all)


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