Abstract
The purpose of this study was to examine the relationship between patient management strategies employed by study personnel, and patient retention and adherence to treatment in the first year of a Phase III clinical trial of interferon beta-1b for treatment of secondary progressive multiple sclerosis (MS). Study staff from each of 35 sites were interviewed regarding patient management practices. Sites which were rated as more empathetic, as instilling a sense of purpose in the patient and promoting less formal relationships with patients had high rates of adherence to treatment. In addressing specific patient concerns, attention to patients' emotional status and patients' expectations of trial participation were related to better adherence.
Original language | English (US) |
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Pages (from-to) | 192-197 |
Number of pages | 6 |
Journal | Multiple Sclerosis |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1999 |
Keywords
- Adherence
- Clinical trials
- Compliance
- Multiple sclerosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology