Treatment center and geographic variability in pre-ESRD care associate with increased mortality

William M. McClellan, Haimanot Wasse, Ann C. McClellan, Adam Kipp, Lance A. Waller, Michael V. Rocco

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Late referral of patients with chronic kidney disease is associated with increased morbidity and mortality, but the contribution of center-to-center and geographic variability of pre-ESRD nephrology care to mortality of patients with ESRD is unknown. We evaluated the pre-ESRD care of >30,000 incident hemodialysis patients, 5088 (17.8%) of whom died during follow-up (median 365 d). Approximately half (51.3%) of incident patients had received at least 6 mo of pre-ESRD nephrology care, as reported by attending physicians. Pre-ESRD nephrology care was independently associated with survival (odds ratio 1.54; 95% confidence interval 1.45 to 1.64). There was substantial center-to-center variability in pre-ESRD care, which was associated with increased facility-specific death rates. As the proportion of patients who were in a treatment center and receiving pre-ESRD nephrology care increased from lowest to highest quintile, the mortality rate decreased from 19.6 to 16.1% (P = 0.0031). In addition, treatment centers in the lowest quintile of pre-ESRD care were clustered geographically. In conclusion, pre-ESRD nephrology care is highly variable among treatment centers and geographic regions. Targeting these disparities could have substantial clinical impact, because the absence of ≥6 mo of pre-ESRD care by a nephrologist is associated with a higher risk for death.

Original languageEnglish (US)
Pages (from-to)1078-1085
Number of pages8
JournalJournal of the American Society of Nephrology
Issue number5
StatePublished - May 2009
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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