TY - JOUR
T1 - Treatment for anomia in bilingual speakers with progressive aphasia
AU - Grasso, Stephanie M.
AU - Peña, Elizabeth D.
AU - Kazemi, Nina
AU - Mirzapour, Haideh
AU - Neupane, Rozen
AU - Bonakdarpour, Borna
AU - Gorno-Tempini, Maria Luisa
AU - Henry, Maya L.
N1 - Funding Information:
Funding: This work was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) Grants, F31DC016229 (awarded to S.M.G.), R01 DC016291 and R03 DC013403 (awarded to M.L.H.), National Institute of Neurological Disorders and Stroke Grant R01 NS050915 and NIDCD Grant K24 DC015544 (awarded to M.L.G.T.).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11
Y1 - 2021/11
N2 - Anomia is an early and prominent feature of primary progressive aphasia (PPA) and other neurodegenerative disorders. Research investigating treatment for lexical retrieval impairment in individuals with progressive anomia has focused primarily on monolingual speakers, and treatment in bilingual speakers is relatively unexplored. In this series of single-case experiments, 10 bilingual speakers with progressive anomia received lexical retrieval treatment designed to engage relatively spared cognitive-linguistic abilities and promote word retrieval. Treatment was administered in two phases, with one language targeted per phase. Cross-linguistic cognates (e.g., rose and rosa) were included as treatment targets to investigate their potential to facilitate cross-linguistic transfer. Performance on trained and untrained stimuli was evaluated before, during, and after each phase of treatment, and at 3, 6, and 12 months post-treatment. Participants demonstrated a significant treatment effect in each of their treated languages, with maintenance up to one year post-treatment for the majority of participants. Most participants showed a significant cross-linguistic transfer effect for trained cognates in both the dominant and nondominant language, with fewer than half of participants showing a significant translation effect for noncognates. A gradual diminution of translation and generalization effects was observed during the follow-up period. Findings support the implementation of dual-language intervention approaches for bilingual speakers with progressive anomia, irrespective of language dominance.
AB - Anomia is an early and prominent feature of primary progressive aphasia (PPA) and other neurodegenerative disorders. Research investigating treatment for lexical retrieval impairment in individuals with progressive anomia has focused primarily on monolingual speakers, and treatment in bilingual speakers is relatively unexplored. In this series of single-case experiments, 10 bilingual speakers with progressive anomia received lexical retrieval treatment designed to engage relatively spared cognitive-linguistic abilities and promote word retrieval. Treatment was administered in two phases, with one language targeted per phase. Cross-linguistic cognates (e.g., rose and rosa) were included as treatment targets to investigate their potential to facilitate cross-linguistic transfer. Performance on trained and untrained stimuli was evaluated before, during, and after each phase of treatment, and at 3, 6, and 12 months post-treatment. Participants demonstrated a significant treatment effect in each of their treated languages, with maintenance up to one year post-treatment for the majority of participants. Most participants showed a significant cross-linguistic transfer effect for trained cognates in both the dominant and nondominant language, with fewer than half of participants showing a significant translation effect for noncognates. A gradual diminution of translation and generalization effects was observed during the follow-up period. Findings support the implementation of dual-language intervention approaches for bilingual speakers with progressive anomia, irrespective of language dominance.
KW - Bilingualism
KW - Intervention
KW - Primary progressive aphasia
KW - Treatment
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U2 - 10.3390/brainsci11111371
DO - 10.3390/brainsci11111371
M3 - Article
C2 - 34827370
AN - SCOPUS:85118208066
SN - 2076-3425
VL - 11
JO - Brain Sciences
JF - Brain Sciences
IS - 11
M1 - 1371
ER -