Treatment of acute promyelocytic leukemia in the very elderly: Case report and review of the literature

Ronald L. Sham*, Martin S. Tallman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Acute promyelocytic leukemia (APL) is the most curable subtype of AML yet it is not known to what extent newer therapies will succeed in the very elderly. Conventional chemotherapeutic induction regimens are usually too toxic for older patients, however, all trans-retinoic acid (ATRA) and arsenic trioxide (ATO) may be useful therapeutic options if used judiciously. This case series describes three octogenarians with APL all treated with ATRA and achieved complete remissions. The last patient received ATO at the time of first relapse and achieved a second remission. To our knowledge, this is the first report of successful use of ATO for induction in an octogenarian with APL.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalLeukemia Research
Volume28
Issue number12
DOIs
StatePublished - Dec 2004

Keywords

  • APL
  • Arsenic trioxide
  • Leukemia
  • Octogenarians
  • Retinoic acid

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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