Treatment of calmodulinopathy with verapamil

Gregory Webster*, Zachary J. Schoppen, Alfred L. George

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Pathological variants in genes encoding calmodulin are associated with severe clinical presentations, including recurrent ventricular fibrillation and sudden death. Beta-receptor antagonists (beta-blockers) and sodium-channel antagonists have been reported as pharmacotherapies in these disorders; however, recent data have demonstrated the importance of derangements in calcium channel inactivation. We report a sustained attempt to use calcium-channel antagonists to treat calmodulinopathy and review the treatment strategies reported in the literature to date.

Original languageEnglish (US)
Article numberbcr-2017-220568
JournalBMJ case reports
Volume2017
DOIs
StatePublished - 2017

Keywords

  • arrhythmias
  • cardiovascular medicine

ASJC Scopus subject areas

  • Medicine(all)

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