Treatment of depression for patients with multiple sclerosis in neurology clinics

David C. Mohr*, S. L. Hart, I. Fonareva, E. S. Tasch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


The objective of this study was to examine the adequacy of antidepressant pharmacotherapy in a sample of patients with multiple sclerosis (MS) treated by neurologists. Methods: MS patients under the care of neurologists were recruited from a large health maintenance organization. Major depressive disorder (MDD) was diagnosed using a structured telephone interview. Antidepressant treatment data were obtained from the HMO pharmacy database. Results: S tudy participants included 260 patients with MS treated by 35 neurologists. A total of 67 (25.8%) patients met the criteria for MDD. Among the patients with MDD, 65.6% received no antidepressant medication, 4.7% received subthreshold doses from their neurologists, 26.6% received doses at threshold, and 3.1% received doses exceeding threshold. Discussion: Depression was undertreated by the neurologists treating this sample of patients with comorbid MS and MDD. Potential solutions are discussed.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalMultiple Sclerosis
Issue number2
StatePublished - Apr 2006


  • Adequacy of care
  • Antidepressant medication
  • Depression
  • Major depressive disorder
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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