Treatment of early Parkinson's disease: Part 1

Tanya Simuni*, Kelly E. Lyons, Rajesh Pahwa, Robert A. Hauser, Cynthia Comella, Lawrence Elmer, Daniel Weintraub

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Scopus citations


The management of early Parkinson's disease (PD) involves the treatment of motor symptoms and, increasingly, non-motor symptoms. Given the fast pace of clinical research in PD, clinicians are faced with the challenge of integrating the latest findings into the ongoing care of individual PD patients. Part 1 of this 2-part article reviews motor symptom efficacy data for the newest PD treatment options, as well as for established therapies. Safety and tolerability data are also reviewed. Part 2 of the article reviews key findings relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms.

Original languageEnglish (US)
Pages (from-to)193-205
Number of pages13
JournalEuropean Neurology
Issue number4
StatePublished - Mar 1 2009


  • Dopamine agonists
  • Levodopa
  • Monoamine oxidase B inhibitors
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Simuni, T., Lyons, K. E., Pahwa, R., Hauser, R. A., Comella, C., Elmer, L., & Weintraub, D. (2009). Treatment of early Parkinson's disease: Part 1. European Neurology, 61(4), 193-205.