Treatment of hepatocellular carcinoma combining sorafenib and transarterial locoregional therapy: State of the science

Joshua L. Weintraub, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalReview article

28 Scopus citations


The potential for increased efficacy with combined transarterial chemoembolization and sorafenib is a topic of increased interest to specialists who care for patients with unresectable hepatocellular carcinoma. There is strong scientific rationale for combination therapy: transarterial chemoembolization produces ischemia and stimulates hypoxia-inducible factor-1α, resulting in a local and systemic upregulation of vascular endothelial growth factor (VEGF), which can increase tumor angiogenesis. This upregulation can theoretically be counteracted with the multikinase inhibitor sorafenib, which is thought to act directly on platelet-derived growth factor, Raf kinase, and VEGF receptors. The potential of this approach has not yet been fully realized in clinical trials, and many unanswered questions remain. This review article discusses the state of the science of arterial locoregional therapies and sorafenib.

Original languageEnglish (US)
Pages (from-to)1123-1134
Number of pages12
JournalJournal of Vascular and Interventional Radiology
Issue number8
StatePublished - Aug 1 2013


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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