Treatment of leptomeningeal carcinomatosis: Current challenges and future opportunities

Manisha Kak, Rita Nanda, Erika Ramsdale, Rimas V. Lukas*

*Corresponding author for this work

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Leptomeningeal metastasis (LM) in breast cancer patients confers a uniformly poor prognosis and decreased quality of life. Treatment options are limited and often ineffective, due in large part to limitations imposed by the blood-brain barrier and the very aggressive nature of this disease. The majority of studies investigating the treatment of LM are not specific to site of origin. Conducting randomized, disease-specific clinical trials in LM is challenging, and much clinical outcomes data are based on case reports or retrospective case series. Multiple studies have suggested that chemo-radiotherapy is superior to either chemotherapy or radiation therapy alone. Attempts to overcome current obstacles in the treatment of breast cancer LM hold promise for the future. We review the epidemiology, diagnosis, and prognosis of LM in breast cancer, and discuss the treatment options currently available as well as those under investigation.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalJournal of Clinical Neuroscience
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Breast cancer
  • Carcinomatous meningitis
  • Chemotherapy
  • Intrathecal therapy
  • Leptomeningeal carcinomatosis
  • Radiotherapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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