Treatment of Malignant Brain Edema and Increased Intracranial Pressure After Stroke

Michael E. Brogan, Edward M. Manno*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The management of patients with large territory ischemic strokes and the subsequent development of malignant brain edema and increased intracranial pressure is a significant challenge in modern neurology and neurocritical care. These patients are at high risk of subsequent neurologic decline and are best cared for in an intensive care unit or a comprehensive stroke center with access to neurosurgical support. Risks include hemorrhagic conversion, herniation, poor functional outcome, and death. This review discusses recent advances in understanding the pathophysiology of edema formation, identifying patients at risk, current management strategies, and emerging therapies.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalCurrent Treatment Options in Neurology
Issue number1
StatePublished - Jan 2015


  • Brain edema
  • Decompressive craniectomy
  • Infarction
  • Intracranial pressure
  • Malignant cerebral edema
  • Patient care management
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Treatment of Malignant Brain Edema and Increased Intracranial Pressure After Stroke'. Together they form a unique fingerprint.

Cite this