TY - JOUR
T1 - Treatment of multiple keratoacanthomas with erlotinib
AU - Reid, David C.
AU - Guitart, Joan
AU - Agulnik, Mark
AU - Lacouture, Mario E.
PY - 2010/8
Y1 - 2010/8
N2 - An 82-year-old male presented with numerous pruritic erythematous nodules over his trunk and extremities. Histopathology was consistent with keratoacanthomas. Given the extent of his disease, medical therapy was recommended. Based on phosphorylated epidermal growth factor receptor expression in lesional keratinocytes, treatment with erlotinib 150 mg daily was initiated, with rapid improvement in the number and appearance of nodules. Immunohistochemistry following treatment revealed a decrease in lesional pEGFR expression, consistent with inhibition of this receptor activation. This is the first report of multiple keratoacanthomas responding to therapy with an EGFR tyrosine kinase inhibitor, and it supports an emerging role for the use of EGFR inhibitors in the management of cutaneous malignancies.
AB - An 82-year-old male presented with numerous pruritic erythematous nodules over his trunk and extremities. Histopathology was consistent with keratoacanthomas. Given the extent of his disease, medical therapy was recommended. Based on phosphorylated epidermal growth factor receptor expression in lesional keratinocytes, treatment with erlotinib 150 mg daily was initiated, with rapid improvement in the number and appearance of nodules. Immunohistochemistry following treatment revealed a decrease in lesional pEGFR expression, consistent with inhibition of this receptor activation. This is the first report of multiple keratoacanthomas responding to therapy with an EGFR tyrosine kinase inhibitor, and it supports an emerging role for the use of EGFR inhibitors in the management of cutaneous malignancies.
KW - Cutaneous malignancy
KW - Epidermal growth factor receptor
KW - Erlotinib
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=77955717413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955717413&partnerID=8YFLogxK
U2 - 10.1007/s10147-010-0047-8
DO - 10.1007/s10147-010-0047-8
M3 - Article
C2 - 20221661
AN - SCOPUS:77955717413
SN - 1341-9625
VL - 15
SP - 413
EP - 415
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 4
ER -