Treatment of Nonmotor Symptoms Associated with Parkinson Disease

Jennifer G. Goldman; Carlos Manuel Guerra

doi:10.1016/j.ncl.2019.12.003

Treatment of Nonmotor Symptoms Associated with Parkinson Disease

Jennifer G. Goldman^*, Carlos Manuel Guerra

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.

Original language	English (US)
Pages (from-to)	269-292
Number of pages	24
Journal	Neurologic clinics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ncl.2019.12.003
State	Published - May 2020

Funding

J.G. Goldman: Grants/research: Michael J. Fox Foundation, Parkinson's Foundation; Consulting: Acadia, Sunovion, WorldwideMed; Honoraria: American Academy of Neurology, International Parkinson's Disease and Movement Disorders Society, Parkinson's Foundation. C.M. Guerra None.

Keywords

Anxiety
Apathy
Autonomic symptoms
Cognition
Dementia
Depression
Psychosis
Sensory symptoms

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2019.12.003

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title = "Treatment of Nonmotor Symptoms Associated with Parkinson Disease",

abstract = "Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.",

keywords = "Anxiety, Apathy, Autonomic symptoms, Cognition, Dementia, Depression, Psychosis, Sensory symptoms",

author = "Goldman, {Jennifer G.} and Guerra, {Carlos Manuel}",

note = "Funding Information: J.G. Goldman: Grants/research: Michael J. Fox Foundation, Parkinson's Foundation; Consulting: Acadia, Sunovion, WorldwideMed; Honoraria: American Academy of Neurology, International Parkinson's Disease and Movement Disorders Society, Parkinson's Foundation. C.M. Guerra None. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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doi = "10.1016/j.ncl.2019.12.003",

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AU - Guerra, Carlos Manuel

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PY - 2020/5

Y1 - 2020/5

N2 - Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.

AB - Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.

KW - Anxiety

KW - Apathy

KW - Autonomic symptoms

KW - Cognition

KW - Dementia

KW - Depression

KW - Psychosis

KW - Sensory symptoms

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Treatment of Nonmotor Symptoms Associated with Parkinson Disease

Abstract

Funding

Keywords

ASJC Scopus subject areas

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