TY - JOUR
T1 - Treatment of Nonmotor Symptoms Associated with Parkinson Disease
AU - Goldman, Jennifer G.
AU - Guerra, Carlos Manuel
N1 - Funding Information:
J.G. Goldman: Grants/research: Michael J. Fox Foundation, Parkinson's Foundation; Consulting: Acadia, Sunovion, WorldwideMed; Honoraria: American Academy of Neurology, International Parkinson's Disease and Movement Disorders Society, Parkinson's Foundation. C.M. Guerra None.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.
AB - Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. These nonmotor symptoms span multiple different systems, invoke multiple different neurotransmitters, and require multiple strategies for treatment including pharmacologic and nonpharmacologic interventions and, often, multiple different disciplines. This article discusses symptoms, assessments, and therapeutics for the nonmotor symptoms of PD including those affecting mood, cognition, behavior, sleep, autonomic function, and sensory systems.
KW - Anxiety
KW - Apathy
KW - Autonomic symptoms
KW - Cognition
KW - Dementia
KW - Depression
KW - Psychosis
KW - Sensory symptoms
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U2 - 10.1016/j.ncl.2019.12.003
DO - 10.1016/j.ncl.2019.12.003
M3 - Review article
C2 - 32279710
AN - SCOPUS:85079362516
SN - 0733-8619
VL - 38
SP - 269
EP - 292
JO - Neurologic Clinics
JF - Neurologic Clinics
IS - 2
ER -