Treatment of stage D bladder cancer with adjuvant doxorubicin hydrochloride and radiation

Anthony J. Schaeffer*, John T. Grayhack, John M. Merrill, George J. Bulkley, Ramananda M. Shetty

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Pathologic Stage D bladder cancer was recognized in 16 patients by evaluation of tissue obtained by radical cystectomy and pelvic lymphadenectomy (7), pelvic lymph node dissection (3) or biopsies (3), ileal conduit and pelvic lymph node biopsy (1), or transurethral biopsy of the bladder and prostate (2). Treatment of these patients with radiation preceded and followed by doxorubicin hydrochloride (Adriamycin) was initiated three to four weeks postoperatively. The treatment regimen consisted of the following: (1) doxorubicin 60 Mg/M2 intravenously every three weeks for three cycles; (2) 5,000 rad external radiation to the whole pelvis in five to six weeks; and (3) doxorubicin for five cycles. The mean survival was twenty-three months. The survival rate was as follows: one year, 10 of 15 patients at risk; two years, 6 of 11; three years, 5 of 9; four years, 1 of 4; and five years, 0 of 2. Ten patients died six to thirty-six months (mean 13.6) postoperatively. In 6 of the patients significant obstruction of small bowel developed. These preliminary observations indicate encouraging therapeutic results with an acceptable morbidity for this regimen.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalUrology
Volume20
Issue number4
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Urology

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