Treatment of stiff‐man syndrome with intravenous immune globulin

Elizabeth W. Karlson, Lewis Sudarsky, Eric Ruderman, Susan Pierson, Mary Scott, Simon M. Helfgott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Objective. To evaluate the efficacy of intravenous immune globulin (IVIG) in the treatment of stiff‐man syndrome (SMS). Methods. An open, unblinded study of 3 patients with active disease and/or disease refractory to treatment with diazepam and/or corticosteroids. Results. All 3 bedridden patients improved substantially shortly after infusion with IVIG and regained function. Conclusion. IVIG may be useful for the treatment of SMS.

Original languageEnglish (US)
Pages (from-to)915-918
Number of pages4
JournalArthritis & Rheumatism
Issue number6
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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