Treatment tolerance of elderly cancer patients entered onto phase II clinical trials: An Illinois Cancer Center study

Susan Giovanazzi-Bannon, Alfred Rademaker, Grace Lai, Al B. Benson*

*Corresponding author for this work

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Purpose: Past research that has compared cancer treatment tolerance between elderly and nonelderly cancer patients has been contradictory. Some investigators concluded that there is no difference between the groups, while others demonstrated elderly patients experienced less tolerance to treatment. As a result, some physicians discriminate against elderly cancer patients by not entering them onto clinical trials out of a belief that they will not tolerate the therapy. Methods: An analysis was performed using the Illinois Cancer Center (ICC) data base, which contains treatment information for all patients registered onto phase II trials. A maximum of 672 cases was available for evaluation of 11 treatment-related variables. Results: The results demonstrated no significant differences between elderly and nonelderly patients for the following seven treatment-related variables: performance status (PS), number of dose reductions, number of treatment interruptions, total days of delay, best response, reason off-study, and number of grade 3 or greater toxicities. Minor differences were detected for number of courses and number of dose escalations. Conclusion: Based on these results, elderly patients should not be denied access to cancer clinical trials relative to age alone.

Original languageEnglish (US)
Pages (from-to)2447-2452
Number of pages6
JournalJournal of Clinical Oncology
Volume12
Issue number11
DOIs
StatePublished - Jan 1 1994

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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