Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a Metropolitan Detroit health system

Tara Reddy*, Teena Chopra, Dror Marchaim, Jason M. Pogue, George Alangaden, Hossein Salimnia, Dina Boikov, Shiri Navon-Venezia, Robert Akins, Philip Selman, Sorabh Dhar, Keith S. Kaye

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from ∼90% to ∼40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrugresistant pathogen.

Original languageEnglish (US)
Pages (from-to)2235-2238
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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