TY - JOUR
T1 - Trends in cardiovascular mortality related to atrial fibrillation in the united states, 2011 to 2018
AU - Tanaka, Yoshihiro
AU - Shah, Nilay S.
AU - Passman, Rod
AU - Greenland, Philip
AU - Lloyd-Jones, Donald M.
AU - Khan, Sadiya S.
N1 - Funding Information:
This work was supported by grants from the American Heart Association (No. 19TPA34890060) to Dr Khan. Research reported in this publication was supported, in part, by the National Institutes of Health’s National Center for Advancing Translational Sciences (grant No. KL2TR001424) to Khan. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by a grant from the American Heart Association (No. 18SFRN43110170) to Dr Tanaka.
Funding Information:
This work was supported by grants from the American Heart Association (No. 19TPA34890060) to Dr Khan. Research reported in this publication was supported, in part, by the National Institutes of Health?s National Center for Advancing Translational Sciences (grant No. KL2TR001424) to Khan. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by a grant from the American Heart Association (No. 18SFRN43110170) to Dr Tanaka.
Publisher Copyright:
© 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2021/8/3
Y1 - 2021/8/3
N2 - BACKGROUND: Prevalence of atrial fibrillation (AF) continues to increase and is associated with significant cardiovascular morbidity and mortality. To inform prevention strategies aimed at reducing the burden of AF, we sought to quantify trends in cardiovascular mortality related to AF in the United States. METHODS AND RESULTS: We performed serial cross-sectional analyses of national death certificate data for cardiovascular mortality related to AF, whereby cardiovascular disease was listed as underlying cause of death and AF as multiple cause of death among adults aged 35 to 84 years using the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research. We calculated age-adjusted mortality rates per 100 000 population and examined trends over time, estimating average annual percentage change using the Joinpoint Regression Program. Subgroup analyses were performed by race-sex and across 2 age groups (younger: 35– 64 years; older: 65– 84 years). A total of 276 373 cardiovascular deaths related to AF were identified in the United States between 2011 and 2018 in decedents aged 35 to 84 years. Age-adjusted mortality rate increased from 18.0 (95% CI, 17.8–18.2) to 22.3 (95% CI, 22.0– 22.4) per 100 000 population between 2011 and 2018. The increase in age-adjusted mortality rate (average annual percentage change) between 2011 and 2018 was greater among younger decedents (7.4% per year [95% CI, 6.8%– 8.0%]) compared with older decedents (3.0% per year [95% CI, 2.6%–3.4%]). CONCLUSIONS: Cardiovascular deaths related to AF are increasing, especially among younger adults, and warrant greater at-tention to prevention earlier in the life course.
AB - BACKGROUND: Prevalence of atrial fibrillation (AF) continues to increase and is associated with significant cardiovascular morbidity and mortality. To inform prevention strategies aimed at reducing the burden of AF, we sought to quantify trends in cardiovascular mortality related to AF in the United States. METHODS AND RESULTS: We performed serial cross-sectional analyses of national death certificate data for cardiovascular mortality related to AF, whereby cardiovascular disease was listed as underlying cause of death and AF as multiple cause of death among adults aged 35 to 84 years using the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research. We calculated age-adjusted mortality rates per 100 000 population and examined trends over time, estimating average annual percentage change using the Joinpoint Regression Program. Subgroup analyses were performed by race-sex and across 2 age groups (younger: 35– 64 years; older: 65– 84 years). A total of 276 373 cardiovascular deaths related to AF were identified in the United States between 2011 and 2018 in decedents aged 35 to 84 years. Age-adjusted mortality rate increased from 18.0 (95% CI, 17.8–18.2) to 22.3 (95% CI, 22.0– 22.4) per 100 000 population between 2011 and 2018. The increase in age-adjusted mortality rate (average annual percentage change) between 2011 and 2018 was greater among younger decedents (7.4% per year [95% CI, 6.8%– 8.0%]) compared with older decedents (3.0% per year [95% CI, 2.6%–3.4%]). CONCLUSIONS: Cardiovascular deaths related to AF are increasing, especially among younger adults, and warrant greater at-tention to prevention earlier in the life course.
KW - Cardiovascular deaths
KW - United states
KW - atrial fibrillation
UR - http://www.scopus.com/inward/record.url?scp=85112053771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85112053771&partnerID=8YFLogxK
U2 - 10.1161/JAHA.120.020163
DO - 10.1161/JAHA.120.020163
M3 - Article
C2 - 34320819
AN - SCOPUS:85112053771
SN - 2047-9980
VL - 10
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 15
M1 - e020163
ER -
