Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo

Irene Georgakoudi; Ellen E. Sheets; Christopher P. Crum; Markus G. Mueller; Vadim Backman; Michael S. Feld

doi:10.1117/12.447118

Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo

Irene Georgakoudi, Ellen E. Sheets, Christopher P. Crum, Markus G. Mueller, Vadim Backman, Michael S. Feld

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4432
DOIs	https://doi.org/10.1117/12.447118
State	Published - Jan 1 2001

Keywords

Biomedical spectroscopy
Cancer diagnosis
Cervical neoplasia
Diffuse reflectance
Fluorescence
Intrinsic fluorescence
Light scattering

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.447118

Cite this

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title = "Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo",

abstract = "Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.",

keywords = "Biomedical spectroscopy, Cancer diagnosis, Cervical neoplasia, Diffuse reflectance, Fluorescence, Intrinsic fluorescence, Light scattering",

author = "Irene Georgakoudi and Sheets, {Ellen E.} and Crum, {Christopher P.} and Mueller, {Markus G.} and Vadim Backman and Feld, {Michael S.}",

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doi = "10.1117/12.447118",

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T1 - Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo

AU - Georgakoudi, Irene

AU - Sheets, Ellen E.

AU - Crum, Christopher P.

AU - Mueller, Markus G.

AU - Backman, Vadim

AU - Feld, Michael S.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

AB - Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

KW - Biomedical spectroscopy

KW - Cancer diagnosis

KW - Cervical neoplasia

KW - Diffuse reflectance

KW - Fluorescence

KW - Intrinsic fluorescence

KW - Light scattering

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

SN - 0277-786X

ER -

Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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