Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo

Irene Georgakoudi, Ellen E. Sheets, Christopher P. Crum, Markus G. Mueller, Vadim Backman, Michael S. Feld

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4432
DOIs
StatePublished - Jan 1 2001

Keywords

  • Biomedical spectroscopy
  • Cancer diagnosis
  • Cervical neoplasia
  • Diffuse reflectance
  • Fluorescence
  • Intrinsic fluorescence
  • Light scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Tri-modal spectroscopy as a tool for detecting cervical squamous intraeptihelial lesions in vivo'. Together they form a unique fingerprint.

Cite this