Triblock peptide-oligonucleotide chimeras (POCs): Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Andrea D. Merg, Ryan V. Thaner, Soumitra Mokashi-Punekar, Sonbinh T. Nguyen*, Nathaniel L. Rosi

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

Original languageEnglish (US)
Pages (from-to)12221-12224
Number of pages4
JournalChemical Communications
Volume53
Issue number90
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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