Triblock peptide-oligonucleotide chimeras (POCs): Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Andrea D. Merg; Ryan V. Thaner; Soumitra Mokashi-Punekar; Sonbinh T. Nguyen; Nathaniel L. Rosi

doi:10.1039/c7cc07708d

Triblock peptide-oligonucleotide chimeras (POCs): Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Andrea D. Merg, Ryan V. Thaner, Soumitra Mokashi-Punekar, Sonbinh T. Nguyen^*, Nathaniel L. Rosi

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

Original language	English (US)
Pages (from-to)	12221-12224
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	90
DOIs	https://doi.org/10.1039/c7cc07708d
State	Published - 2017

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Triblock peptide-oligonucleotide chimeras (POCs): Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials",

abstract = "Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.",

author = "Merg, {Andrea D.} and Thaner, {Ryan V.} and Soumitra Mokashi-Punekar and Nguyen, {Sonbinh T.} and Rosi, {Nathaniel L.}",

note = "Funding Information: We acknowledge the Air Force Office of Scientific Research (FA9550-11-1-0275, N. L. R. and S. T. N.) for financial support. R. V. T. acknowledges a NSF Graduate Research Fellowship (DGE-1324585). We also thank the Petersen NFCF for access to SEM instrumentation. Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc07708d",

language = "English (US)",

volume = "53",

pages = "12221--12224",

journal = "Chemical Communications",

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T1 - Triblock peptide-oligonucleotide chimeras (POCs)

T2 - Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

AU - Merg, Andrea D.

AU - Thaner, Ryan V.

AU - Mokashi-Punekar, Soumitra

AU - Nguyen, Sonbinh T.

AU - Rosi, Nathaniel L.

N1 - Funding Information: We acknowledge the Air Force Office of Scientific Research (FA9550-11-1-0275, N. L. R. and S. T. N.) for financial support. R. V. T. acknowledges a NSF Graduate Research Fellowship (DGE-1324585). We also thank the Petersen NFCF for access to SEM instrumentation. Publisher Copyright: © 2017 The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

AB - Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

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JF - Chemical Communications

SN - 1359-7345

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Triblock peptide-oligonucleotide chimeras (POCs): Programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Abstract

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