Tricuspid regurgitant jet velocity is associated with hemolysis in children and young adults with sickle cell disease evaluated for pulmonary hypertension

Robert I Liem*, Luciana T. Young, Alexis A Thompson

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Tricuspid regurgitant jet velocity (TRJV) ≥2.5 m/sec. on echocardiography is a surrogate marker for pulmonary hypertension (PHT) in adults with sickle cell disease (SCD). We prospectively examined the relationship between TRJV and laboratory markers of hemolysis in 51 children and young adults with SCD at baseline. We found significant correlations between TRJV and lactate dehydrogenase (LDH), hemoglobin (Hb), reticulocyte count (retic) and aspartate aminotransferase (AST). LDH, retic and AST were significantly higher and Hb was lower in subjects with TRJV ≥2.5 m/sec. We conclude that hemolysis significantly contributes to TRJV elevation in children and young adults with SCD.

Original languageEnglish (US)
Pages (from-to)1549-1552
Number of pages4
JournalHaematologica
Volume92
Issue number11
DOIs
StatePublished - Nov 1 2007

Keywords

  • Hemolysis
  • Lactate dehydrogenase
  • Pulmonary hypertension
  • Sickle cell disease
  • Tricuspid regurgitant jet velocity

ASJC Scopus subject areas

  • Hematology

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