Tricuspid regurgitation progression and regression in pulmonary arterial hypertension: Implications for right ventricular and tricuspid valve apparatus geometry and patients outcome

Diego Medvedofsky, Doron Aronson, Mardi Gomberg-Maitland, Vasiliki Thomeas, Stuart Rich, Kirk Spencer, Victor Mor-Avi, Karima Addetia, Roberto M. Lang, Avinoam Shiran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Aims The aim of this study was to determine the mechanism of tricuspid regurgitation (TR) progression in pulmonary arterial hypertension (PAH) and its effect on survival. Methods and results We studied 88 patients with PAH and functional TR (mean pulmonary artery pressure 49+14 mmHg; 43% idiopathic PAH) who had serial echocardiograms. TR progression (n = 35) was defined as ≤mild TR on Echo 1 and ≥moderate TR on Echo 2. TR regression (n = 17) was defined as ≥moderate TR on Echo 1 and ≤mild TR on Echo 2. Stable TR (n = 36) was defined as ≤mild TR on both echoes. TR progression was associated with an increase in pulmonary artery systolic pressure (PASP, 62±22-92±23 mmHg, P < 0.0001), right ventricular (RV) enlargement, mainly at midventricular level, increased RV sphericity (6.1±1.7-6.9±1.8, P = 0.004), tricuspid annular (TA) dilatation (4.0+0.7-4.6+0.7 cm, P < 0.0001), and increased tricuspid valve (TV) tenting area (2.0+0.7-2.5+1.0 cm2, P=0.0003). TR regression was associated with a reduction in PASP (84±15-55±18 mmHg, P , 0.0001), reverse RV remodelling with a reduction in RV sphericity (6.3±1.4-5.5±1.0, P = 0.02), and a reduction in TA size (4.1±0.7-3.6±0.7 cm, P = 0.02) and TV tenting (2.1±0.7-1.3+0.5 cm2, P = 0.0002). TR progression was associated with all-cause mortality (log-rank P = 0.0007). Conclusion In PAH, TR progression was associated with worsening pulmonary hypertension and adverse RV and TV apparatus remodelling. TR progression is associated with poor outcome in PAH.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalEuropean heart journal cardiovascular Imaging
Volume18
Issue number1
DOIs
StatePublished - Jan 2017

Keywords

  • Progression
  • Pulmonary arterial hypertension
  • Regression
  • Remodelling
  • Tricuspid regurgitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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