Tricyclic dose requirements across pregnancy

Katherine L. Wisner*, James M. Perel, Susan B. Wheeler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


In a series of eight pregnant women, the authors found that the doses of tricyclic antide-pressants required to achieve remission of symptoms and adequate serum levels increased during the second half of pregnancy. During the final trimester, the mean dose required was 1.6 times the mean dose required when the patients were not pregnant.

Original languageEnglish (US)
Pages (from-to)1541-1542
Number of pages2
JournalAmerican Journal of Psychiatry
Issue number10
StatePublished - 1993

ASJC Scopus subject areas

  • Psychiatry and Mental health


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