Tricyclics vs SSRIs for postpartum depression

K. L. Wisner*, K. S. Peindl, T. V. Gigliotti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: We investigated whether differential responsivity to tricyclics (TCA) compared to serotonin specific reuptake inhibitors (SSRI) occurred in our clinical population of women with postpartum depression. Method: Sequential records (N = 35) of women with non-psychotic, non-bipolar, postparrum-onset major depression were reviewed to determine drug response. Response was defined as 50% reduction in the initial depression score by week 8 of treatment. Results: The response rate was 67% for TCA was 79% for SSRI. The five nonresponders to TCA were treated with an SSRI, and four (80%) were effectively treated. Discussion: This naturalistic data obtained from our clinic supports that SSRI are superior to TCA for the treatment of postpartum major depression. The difference in percent response (12%) is similar to that of other studies in which TCA were compared to SSRI for treatment depression in women.

Original languageEnglish (US)
Pages (from-to)189-191
Number of pages3
JournalArchives of Women's Mental Health
Issue number4
StatePublished - Dec 1 1998


  • Antidepressants
  • Postpartum depression
  • Serotonin specific reuptake inhibitors
  • Tricyclics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health


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