TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

Deguan Lv, Yanxin Li, Weiwei Zhang, Angel A Alvarez, Lina Song, Jianming Tang, Wei Qiang Gao, Bo Hu, Shi-Yuan Cheng, Haizhong Feng*

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aberrant amplification and mutations of epidermal growth factor receptor (EGFR) are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive pathogenesis are not well understood. Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis. In multiple glioma cell lines and patient-derived glioma stem cells (GSCs), EGFR signaling promotes H3K23 acetylation and association with TRIM24. Consequently, TRIM24 functions as a transcriptional co-activator and recruits STAT3, leading to stabilized STAT3-chromatin interactions and subsequent activation of STAT3 downstream signaling, thereby enhancing EGFR-driven tumorigenesis. Our findings uncover a pathway in which TRIM24 functions as a signal relay for oncogenic EGFR signaling and suggest TRIM24 as a potential therapeutic target for GBM that are associated with EGFR activation.

Original languageEnglish (US)
Article number1454
JournalNature communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Glioblastoma
Epidermal Growth Factor Receptor
Glioma
Carcinogenesis
Chemical activation
activation
acetylation
Acetylation
pathogenesis
chromatin
Amino Acid Motifs
stem cells
lysine
relay
mutations
Stem cells
cultured cells
Histones
Lysine
Chromatin

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lv, Deguan ; Li, Yanxin ; Zhang, Weiwei ; Alvarez, Angel A ; Song, Lina ; Tang, Jianming ; Gao, Wei Qiang ; Hu, Bo ; Cheng, Shi-Yuan ; Feng, Haizhong. / TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma. In: Nature communications. 2017 ; Vol. 8, No. 1.
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abstract = "Aberrant amplification and mutations of epidermal growth factor receptor (EGFR) are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive pathogenesis are not well understood. Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis. In multiple glioma cell lines and patient-derived glioma stem cells (GSCs), EGFR signaling promotes H3K23 acetylation and association with TRIM24. Consequently, TRIM24 functions as a transcriptional co-activator and recruits STAT3, leading to stabilized STAT3-chromatin interactions and subsequent activation of STAT3 downstream signaling, thereby enhancing EGFR-driven tumorigenesis. Our findings uncover a pathway in which TRIM24 functions as a signal relay for oncogenic EGFR signaling and suggest TRIM24 as a potential therapeutic target for GBM that are associated with EGFR activation.",
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TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma. / Lv, Deguan; Li, Yanxin; Zhang, Weiwei; Alvarez, Angel A; Song, Lina; Tang, Jianming; Gao, Wei Qiang; Hu, Bo; Cheng, Shi-Yuan; Feng, Haizhong.

In: Nature communications, Vol. 8, No. 1, 1454, 01.12.2017.

Research output: Contribution to journalArticle

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AU - Lv, Deguan

AU - Li, Yanxin

AU - Zhang, Weiwei

AU - Alvarez, Angel A

AU - Song, Lina

AU - Tang, Jianming

AU - Gao, Wei Qiang

AU - Hu, Bo

AU - Cheng, Shi-Yuan

AU - Feng, Haizhong

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