Trimethoprim-Sulfamethoxazole Oral Desensitization in Hemophiliacs Infected With Human Immunodeficiency Virus With a History of Hypersensitivity Reactions

Morris Kletzel*, Suzanne Beck, Joe Elser, Nikki Shock, Wesley Burks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Hemophiliacs infected with human immunodeficiency virus with a history of hypersensitivity reaction to a combination product of trimethoprim and sulfamethoxazole were desensitized orally. Six of the seven patients included in the study successfully completed the desensitization protocol and received trimethoprim-sulfamethoxazole for 5 to 7 months after desensitization (mean length of treatment, 5.7 months) for prophylaxis of Pneumocystis carinii pneumonia. The small number of patients and the short follow-up allow us to suggest that oral desensitization may be an effective and inexpensive means to treat hemophiliacs infected with human immunodeficiency virus with trimethoprim-sulfamethoxazole as prophylaxis against Pneumocystis carinii pneumonia.

Original languageEnglish (US)
Pages (from-to)1428-1429
Number of pages2
JournalAmerican Journal of Diseases of Children
Volume145
Issue number12
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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