Triphenylmethylphosphonium Trichloro (caffeine) platinum (II), [P(C6H5)3(CH3)][PtCl3(caffeine)], Structure and Anticancer Activity

Roger E. Cramer, Douglas M. Ho, William Van Doorne, James A Ibers, Ted Norton, Midori Kashiwagi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The salt [PPh3Me] [PtCl3(caffeine)] has been synthesized and its structure determined. It crystallizes in the triclinic space group Ci1-P1 with cell dimensions at -162 °C of a = 12.332 (5) Å, b = 13.230 (6) Å, c = 8.712 (4) Å, α = 97.07 (2)°, β = 99.78 (4)°, γ = 93.63 (1)°, V = 1385 Å3, and Z = 2. The structure was solved by heavy-atom methods, and the 217 variables were refined by least-squares techniques to a final R index on F of 0.038 for the 5670 data. The structure consists of discrete [PPh3Me]+ cations and [PtCl3(caffeine)]- anions. The square-planar Pt(II) ion is bound to atom N(9) of the caffeine ligand at a distance of 2.021 (5) Å. The related salt K[PtCl3(caffeine)] has significant anticancer activity.

Original languageEnglish (US)
Pages (from-to)2457-2461
Number of pages5
JournalInorganic chemistry
Volume20
Issue number8
DOIs
StatePublished - Jan 1 1981

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caffeine
Caffeine
Platinum
platinum
Salts
salts
Atoms
Anions
atoms
Cations
Ions
anions
Ligands
cations
ligands
triphenylmethylphosphonium
cells
ions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this

Cramer, Roger E. ; Ho, Douglas M. ; Van Doorne, William ; Ibers, James A ; Norton, Ted ; Kashiwagi, Midori. / Triphenylmethylphosphonium Trichloro (caffeine) platinum (II), [P(C6H5)3(CH3)][PtCl3(caffeine)], Structure and Anticancer Activity. In: Inorganic chemistry. 1981 ; Vol. 20, No. 8. pp. 2457-2461.
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abstract = "The salt [PPh3Me] [PtCl3(caffeine)] has been synthesized and its structure determined. It crystallizes in the triclinic space group Ci1-P1 with cell dimensions at -162 °C of a = 12.332 (5) {\AA}, b = 13.230 (6) {\AA}, c = 8.712 (4) {\AA}, α = 97.07 (2)°, β = 99.78 (4)°, γ = 93.63 (1)°, V = 1385 {\AA}3, and Z = 2. The structure was solved by heavy-atom methods, and the 217 variables were refined by least-squares techniques to a final R index on F of 0.038 for the 5670 data. The structure consists of discrete [PPh3Me]+ cations and [PtCl3(caffeine)]- anions. The square-planar Pt(II) ion is bound to atom N(9) of the caffeine ligand at a distance of 2.021 (5) {\AA}. The related salt K[PtCl3(caffeine)] has significant anticancer activity.",
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Triphenylmethylphosphonium Trichloro (caffeine) platinum (II), [P(C6H5)3(CH3)][PtCl3(caffeine)], Structure and Anticancer Activity. / Cramer, Roger E.; Ho, Douglas M.; Van Doorne, William; Ibers, James A; Norton, Ted; Kashiwagi, Midori.

In: Inorganic chemistry, Vol. 20, No. 8, 01.01.1981, p. 2457-2461.

Research output: Contribution to journalArticle

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AU - Cramer, Roger E.

AU - Ho, Douglas M.

AU - Van Doorne, William

AU - Ibers, James A

AU - Norton, Ted

AU - Kashiwagi, Midori

PY - 1981/1/1

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N2 - The salt [PPh3Me] [PtCl3(caffeine)] has been synthesized and its structure determined. It crystallizes in the triclinic space group Ci1-P1 with cell dimensions at -162 °C of a = 12.332 (5) Å, b = 13.230 (6) Å, c = 8.712 (4) Å, α = 97.07 (2)°, β = 99.78 (4)°, γ = 93.63 (1)°, V = 1385 Å3, and Z = 2. The structure was solved by heavy-atom methods, and the 217 variables were refined by least-squares techniques to a final R index on F of 0.038 for the 5670 data. The structure consists of discrete [PPh3Me]+ cations and [PtCl3(caffeine)]- anions. The square-planar Pt(II) ion is bound to atom N(9) of the caffeine ligand at a distance of 2.021 (5) Å. The related salt K[PtCl3(caffeine)] has significant anticancer activity.

AB - The salt [PPh3Me] [PtCl3(caffeine)] has been synthesized and its structure determined. It crystallizes in the triclinic space group Ci1-P1 with cell dimensions at -162 °C of a = 12.332 (5) Å, b = 13.230 (6) Å, c = 8.712 (4) Å, α = 97.07 (2)°, β = 99.78 (4)°, γ = 93.63 (1)°, V = 1385 Å3, and Z = 2. The structure was solved by heavy-atom methods, and the 217 variables were refined by least-squares techniques to a final R index on F of 0.038 for the 5670 data. The structure consists of discrete [PPh3Me]+ cations and [PtCl3(caffeine)]- anions. The square-planar Pt(II) ion is bound to atom N(9) of the caffeine ligand at a distance of 2.021 (5) Å. The related salt K[PtCl3(caffeine)] has significant anticancer activity.

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