Triphenylmethylphosphonium Trichloro (caffeine) platinum (II), [P(C6H5)3(CH3)][PtCl3(caffeine)], Structure and Anticancer Activity

Roger E. Cramer, Douglas M. Ho, William Van Doorne, James A. Ibers, Ted Norton, Midori Kashiwagi

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Abstract

The salt [PPh3Me] [PtCl3(caffeine)] has been synthesized and its structure determined. It crystallizes in the triclinic space group Ci1-P1 with cell dimensions at -162 °C of a = 12.332 (5) Å, b = 13.230 (6) Å, c = 8.712 (4) Å, α = 97.07 (2)°, β = 99.78 (4)°, γ = 93.63 (1)°, V = 1385 Å3, and Z = 2. The structure was solved by heavy-atom methods, and the 217 variables were refined by least-squares techniques to a final R index on F of 0.038 for the 5670 data. The structure consists of discrete [PPh3Me]+ cations and [PtCl3(caffeine)]- anions. The square-planar Pt(II) ion is bound to atom N(9) of the caffeine ligand at a distance of 2.021 (5) Å. The related salt K[PtCl3(caffeine)] has significant anticancer activity.

Original languageEnglish (US)
Pages (from-to)2457-2461
Number of pages5
JournalInorganic chemistry
Volume20
Issue number8
DOIs
StatePublished - Aug 1981

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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