Troponin I elevation and cardiac events after percutaneous coronary intervention

Mark J Ricciardi, Charles J Davidson*, George Gubernikoff, Nirat Beohar, Lorene J. Eckman, Michele A. Parker, Robert O Bonow

*Corresponding author for this work

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Background: Serum troponins are sensitive markers of myonecrosis and ischemia and are now widely used in clinical practice. Although percutaneous coronary intervention (PCI)-related creatine kinase-myocardial band isoenzyme (CK-MB) elevation has been associated with future cardiac events, the significance of troponin elevation in this setting is unknown. We sought to determine whether serum troponin I (Tn-I) elevation after PCI is associated with future cardiac events. Methods and Results: Consecutive patients undergoing elective PCI underwent systematic postprocedure measurement of Tn-I and CK-MB levels. Serum levels were correlated with demographic, angiographic, and procedural characteristics and the development of major adverse cardiac events (MACE; defined as death, MI, or need for PCI or coronary bypass graft surgery) at 30 days, 6 months, and 1 year. In 286 consecutive procedures, postintervention myonecrosis-specific Tn-I was elevated in 13.6% of patients, and CK-MB was elevated in 12.9% of patients. Multivariable predictors of Tn-I elevation were procedural side branch occlusion and thrombus formation. Peak Tn-I and CK-MB values were well correlated (r = 0.81, P < .0001). Three-fold elevation of Tn-I after successful PCI was independently predictive of MACE (P = .01). Conclusions: Tn-I elevation after elective PCI is relatively common and is associated with procedural complications such as incidental side branch occlusion and thrombus formation. In addition, this study demonstrates that a 3-fold elevation of Tn-I after successful elective PCI is predictive of future cardiac events, especially the need for early repeat revascularization.

Original languageEnglish (US)
Pages (from-to)522-528
Number of pages7
JournalAmerican heart journal
Volume145
Issue number3
DOIs
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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