TRPA1

Jaime Garcia-Anoveros*, K. Nagata

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Citations (Scopus)

Abstract

The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs. In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear. In nociceptive neurons, TRPA1 mediates the response to the proalgesic bradykinin as well as the response to pungent irritants found in mustards and garlic, and probably also to those found in cinnamon and tear gas. The channel properties of TRPA1 are discussed and compared to those of sensory transducers. TRPA1 is well conserved across the animal kingdom, with likely orthologs from human to nematode, which suggest an ancestral role for this channel, probably in sensation.

Original languageEnglish (US)
Title of host publicationTransient Receptor Potential (TRP) Channels
EditorsVeit Flockerzi, Bernd Nilius
Pages347-362
Number of pages16
DOIs
StatePublished - Dec 1 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume179
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Fingerprint

Nociceptors
Neurons
Tear Gases
Ankyrin Repeat
Cinnamomum zeylanicum
Garlic
Mustard Plant
Irritants
Bradykinin
Inner Ear
Transducers
Ganglia
Animals
Epithelium
Membranes
Proteins

Keywords

  • A-G-35
  • AITC
  • Adaptation
  • Allyl isothiocyanate
  • Amiloride
  • Calcium
  • Channel
  • Channel potentiation
  • Desensitization
  • Gadolinium
  • Gentamicin
  • Hair cell
  • Hearing
  • Hyperalgesia
  • Icilin
  • Inactivation
  • Inner ear
  • Mechanotransduction
  • Mustard oil
  • Nociceptor
  • Pain
  • Ruthenium red
  • Sensory transduction
  • Support cell

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Garcia-Anoveros, J., & Nagata, K. (2007). TRPA1. In V. Flockerzi, & B. Nilius (Eds.), Transient Receptor Potential (TRP) Channels (pp. 347-362). (Handbook of Experimental Pharmacology; Vol. 179). https://doi.org/10.1007/978-3-540-34891-7_21
Garcia-Anoveros, Jaime ; Nagata, K. / TRPA1. Transient Receptor Potential (TRP) Channels. editor / Veit Flockerzi ; Bernd Nilius. 2007. pp. 347-362 (Handbook of Experimental Pharmacology).
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Garcia-Anoveros, J & Nagata, K 2007, TRPA1. in V Flockerzi & B Nilius (eds), Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol. 179, pp. 347-362. https://doi.org/10.1007/978-3-540-34891-7_21

TRPA1. / Garcia-Anoveros, Jaime; Nagata, K.

Transient Receptor Potential (TRP) Channels. ed. / Veit Flockerzi; Bernd Nilius. 2007. p. 347-362 (Handbook of Experimental Pharmacology; Vol. 179).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs. In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear. In nociceptive neurons, TRPA1 mediates the response to the proalgesic bradykinin as well as the response to pungent irritants found in mustards and garlic, and probably also to those found in cinnamon and tear gas. The channel properties of TRPA1 are discussed and compared to those of sensory transducers. TRPA1 is well conserved across the animal kingdom, with likely orthologs from human to nematode, which suggest an ancestral role for this channel, probably in sensation.

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KW - Gadolinium

KW - Gentamicin

KW - Hair cell

KW - Hearing

KW - Hyperalgesia

KW - Icilin

KW - Inactivation

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KW - Mechanotransduction

KW - Mustard oil

KW - Nociceptor

KW - Pain

KW - Ruthenium red

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Garcia-Anoveros J, Nagata K. TRPA1. In Flockerzi V, Nilius B, editors, Transient Receptor Potential (TRP) Channels. 2007. p. 347-362. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-540-34891-7_21