TRPC5 is a regulator of hippocampal neurite length and growth cone morphology

Anna Greka, Betsy Navarro, Elena Oancea, Anne Duggan, David E. Clapham*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

301 Scopus citations


Growth cone motility is regulated by both fast voltage-dependent Ca2+ channels and by unknown receptor-operated Ca2+ entry mechanisms. Transient receptor potential (TRP) homomeric TRPC5 ion channels are receptor-operated, Ca2+-permeable channels predominantly expressed in the brain. Here we show that TRPC5 is expressed in growth cones of young rat hippocampal neurons. Our results indicate that TRPC5 channel subunits interact with the growth cone-enriched protein stathmin 2, are packaged into vesicles and are carried to newly forming growth cones and synapses. Once in the growth cone, TRPC5 channels regulate neurite extension and growth-cone morphology. Dominant-negative TRPC5 expression allowed significantly longer neurites and filopodia to form. We conclude that TRPC5 channels are important components of the mechanism controlling neurite extension and growth cone morphology.

Original languageEnglish (US)
Pages (from-to)837-845
Number of pages9
JournalNature neuroscience
Issue number8
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)


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