Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

Ji Young Lee; Tiffany R. Glynn; Judith T. Moskowitz; Dietmar Fuchs; Torsten B. Neilands; Samantha E. Dilworth; Daniel J. Feaster; Allan Rodriguez; Adam W. Carrico

doi:10.1007/s13365-020-00937-x

Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

Ji Young Lee, Tiffany R. Glynn, Judith T. Moskowitz, Dietmar Fuchs, Torsten B. Neilands, Samantha E. Dilworth, Daniel J. Feaster, Allan Rodriguez, Adam W. Carrico^*

^*Corresponding author for this work

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15 months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27; p = 0.036). Future clinical research should examine whether bio-behavioral interventions targeting tryptophan degradation could optimize treatments for people living with co-occurring HIV and stimulant use disorders.

Original language	English (US)
Pages (from-to)	178-182
Number of pages	5
Journal	Journal of neurovirology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/s13365-020-00937-x
State	Published - Feb 2021

Keywords

HIV
Immune activation
Methamphetamine
Positive affect
Tryptophan

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13365-020-00937-x

Cite this

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title = "Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine",

abstract = "This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15 months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27; p = 0.036). Future clinical research should examine whether bio-behavioral interventions targeting tryptophan degradation could optimize treatments for people living with co-occurring HIV and stimulant use disorders.",

keywords = "HIV, Immune activation, Methamphetamine, Positive affect, Tryptophan",

author = "Lee, {Ji Young} and Glynn, {Tiffany R.} and Moskowitz, {Judith T.} and Dietmar Fuchs and Neilands, {Torsten B.} and Dilworth, {Samantha E.} and Feaster, {Daniel J.} and Allan Rodriguez and Carrico, {Adam W.}",

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doi = "10.1007/s13365-020-00937-x",

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T1 - Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

AU - Lee, Ji Young

AU - Glynn, Tiffany R.

AU - Moskowitz, Judith T.

AU - Fuchs, Dietmar

AU - Neilands, Torsten B.

AU - Dilworth, Samantha E.

AU - Feaster, Daniel J.

AU - Rodriguez, Allan

AU - Carrico, Adam W.

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N2 - This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15 months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27; p = 0.036). Future clinical research should examine whether bio-behavioral interventions targeting tryptophan degradation could optimize treatments for people living with co-occurring HIV and stimulant use disorders.

AB - This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15 months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27; p = 0.036). Future clinical research should examine whether bio-behavioral interventions targeting tryptophan degradation could optimize treatments for people living with co-occurring HIV and stimulant use disorders.

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KW - Immune activation

KW - Methamphetamine

KW - Positive affect

KW - Tryptophan

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Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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