TY - JOUR
T1 - Tryptophan metabolism in brain tumors — IDO and beyond
AU - Platten, Michael
AU - Friedrich, Mirco
AU - Wainwright, Derek A.
AU - Panitz, Verena
AU - Opitz, Christiane A.
N1 - Funding Information:
This work was supported by grants from the German Cancer Aid ( 70113515 ) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ( 406052676 ; PL-315/5-1) to M.P. This work was supported in part by National Institutes of Health (NIH) P50 CA221747 (D.A.W.), NIH R01 NS097851 (D.A.W.), NIH K02 AG068617 (D.A.W.), BrainUp grant 2136 (D.A.W.), the Gail Boyter Magness (GBM) Foundation (D.A.W.), the Grace Giving Foundation (D.A.W.), the Stephen Coffman Charitable Trust (D.A.W.), and the 5 for the Fight organization (D.A.W.). V.P. was supported by the DKFZ Clinician Scientist Program and the Dieter Morszeck Foundation . M.F. is member of the MD/PhD program at Heidelberg University. M.F. received fellowships by the Heidelberg Biosciences International Graduate School (HBIGS), the German Academic Exchange Service (DAAD) and the Excellence Initiative of the German Council of Science and Humanities and the German Research Foundation (DFG). M.P. and C.A.O. were supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)–Project-ID 404521405, SFB 1389–UNITE Glioblastoma.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - Metabolism of the essential amino acid tryptophan is a key metabolic pathway that restricts antitumor immunity and is a drug development target for cancer immunotherapy. Tryptophan metabolism is active in brain tumors including gliomas and promotes a malignant phenotype and contributes to the immunosuppressive tumor microenvironment. In recent years, improved understanding of the regulation and downstream function of tryptophan metabolism has been significantly expanded beyond the initial in vitro observation that the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) promotes the depletion of intracellular tryptophan. Here, we revisit the specific roles of tryptophan metabolites in regulating brain functioning and neuronal integrity as well as in the context of brain tumors.
AB - Metabolism of the essential amino acid tryptophan is a key metabolic pathway that restricts antitumor immunity and is a drug development target for cancer immunotherapy. Tryptophan metabolism is active in brain tumors including gliomas and promotes a malignant phenotype and contributes to the immunosuppressive tumor microenvironment. In recent years, improved understanding of the regulation and downstream function of tryptophan metabolism has been significantly expanded beyond the initial in vitro observation that the enzyme indoleamine-2,3-dioxygenase 1 (IDO1) promotes the depletion of intracellular tryptophan. Here, we revisit the specific roles of tryptophan metabolites in regulating brain functioning and neuronal integrity as well as in the context of brain tumors.
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U2 - 10.1016/j.coi.2021.03.005
DO - 10.1016/j.coi.2021.03.005
M3 - Review article
C2 - 33813026
AN - SCOPUS:85103592149
SN - 0952-7915
VL - 70
SP - 57
EP - 66
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -
