T1 and T2 relaxivities of succimer-coated MFe23+O4 (M=Mn2+, Fe2+ and Co2+) inverse spinel ferrites for potential use as phase-contrast agents in medical MRI

Dong Hyun Kim, Huadong Zeng, Thian C. Ng, Christopher S. Brazel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Superparamagnetic MFe23+O4 (M=Mn2+, Fe2+ and Co2+) inverse spinel ferrite (ISF) nanoparticles with narrow size distribution having average diameters of 6-8 nm were synthesized by a diol reduction of organic metals and the surface was modified to be hydrophilic by coating with succimer. Magnetic resonance imaging (MRI) contrast enhancement by dipolar coupling defined interactions between the synthesized ISFs and protons in the bulk water was investigated with initial susceptibility, magnetization and anisotropy of the succimer-coated ISFs. The relaxivity ratios, r2/r1, for MnFe2O4, Fe3O4 and CoFe2O4 were measured to be 12.2, 23.1 and 62.3, respectively, which demonstrate the potential usefulness of these magnetic nanoparticles as T2 contrast agents for MRI.

Original languageEnglish (US)
Pages (from-to)3899-3904
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Issue number23
StatePublished - Dec 2009


  • Ferrites Magnetic Nanoparticles Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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