TY - JOUR
T1 - T1 and T2 relaxivities of succimer-coated MFe23+O4 (M=Mn2+, Fe2+ and Co2+) inverse spinel ferrites for potential use as phase-contrast agents in medical MRI
AU - Kim, Dong Hyun
AU - Zeng, Huadong
AU - Ng, Thian C.
AU - Brazel, Christopher S.
N1 - Funding Information:
This project was funded through The University of Alabama's Alton Scott Memorial Fund and through a grant to Dr. Kim by a Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-D00092). Dr. Brazel also acknowledges the support of the Fulbright Commission for funding his 2008–2009 sabbatical as a visiting professor and distinguished scholar at Keele University's Institute for Science and Technology in Medicine, Stoke-on-Trent, United Kingdom.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/12
Y1 - 2009/12
N2 - Superparamagnetic MFe23+O4 (M=Mn2+, Fe2+ and Co2+) inverse spinel ferrite (ISF) nanoparticles with narrow size distribution having average diameters of 6-8 nm were synthesized by a diol reduction of organic metals and the surface was modified to be hydrophilic by coating with succimer. Magnetic resonance imaging (MRI) contrast enhancement by dipolar coupling defined interactions between the synthesized ISFs and protons in the bulk water was investigated with initial susceptibility, magnetization and anisotropy of the succimer-coated ISFs. The relaxivity ratios, r2/r1, for MnFe2O4, Fe3O4 and CoFe2O4 were measured to be 12.2, 23.1 and 62.3, respectively, which demonstrate the potential usefulness of these magnetic nanoparticles as T2 contrast agents for MRI.
AB - Superparamagnetic MFe23+O4 (M=Mn2+, Fe2+ and Co2+) inverse spinel ferrite (ISF) nanoparticles with narrow size distribution having average diameters of 6-8 nm were synthesized by a diol reduction of organic metals and the surface was modified to be hydrophilic by coating with succimer. Magnetic resonance imaging (MRI) contrast enhancement by dipolar coupling defined interactions between the synthesized ISFs and protons in the bulk water was investigated with initial susceptibility, magnetization and anisotropy of the succimer-coated ISFs. The relaxivity ratios, r2/r1, for MnFe2O4, Fe3O4 and CoFe2O4 were measured to be 12.2, 23.1 and 62.3, respectively, which demonstrate the potential usefulness of these magnetic nanoparticles as T2 contrast agents for MRI.
KW - Ferrites Magnetic Nanoparticles Magnetic Resonance Imaging
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U2 - 10.1016/j.jmmm.2009.07.057
DO - 10.1016/j.jmmm.2009.07.057
M3 - Article
AN - SCOPUS:70049099694
VL - 321
SP - 3899
EP - 3904
JO - Journal of Magnetism and Magnetic Materials
JF - Journal of Magnetism and Magnetic Materials
SN - 0304-8853
IS - 23
ER -