TH2 adjuvants: Implications for food allergy

M. Cecilia Berin, Wayne G. Shreffler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

A persistent question for immunologists studying allergic disease has been to define the characteristics of a molecule that make it allergenic. There has been substantial progress elucidating mechanisms of innate priming of TH2 immunity in the past several years. These accumulating data demonstrate that TH2 immunity is actively induced by an array of molecules, many of which were first discovered in the context of antihelminthic immune responses. Similar intrinsic or associated activities are now known to account for the TH2 immunogenicity of some allergens, and may prove to play a role for many more. In this review, we discuss what has been discovered regarding molecules that induce innate immune activation and the pathways that promote TH2-polarized immune responses generally, and specifically what role these mechanisms may play in food allergy from models of food allergy and the study of TH2 gastrointestinal adjuvants.

Original languageEnglish (US)
Pages (from-to)1311-1320
Number of pages10
JournalJournal of Allergy and Clinical Immunology
Volume121
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Adjuvant
  • DC-SIGN
  • Delta
  • Jagged
  • Notch
  • OX40L
  • T-cell immunoglobulin mucin protein
  • T2
  • TSLP
  • allergen
  • cholera toxin
  • food allergy
  • glycan
  • helminth
  • protease
  • protease activated receptor
  • superallergen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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