TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: Evidence of a nonimmunologic etiology

Andrew M. Evens, Hau C. Kwaan, Dixon B. Kaufman, Charles L. Bennett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background. One recently reported thrombotic thrombocytopenia purpura/hemolytic uremic syndrome (TTP/HUS) case involved a patient who underwent simultaneous pancreas/kidney (SPK) transplant followed by pancreas rejection and clopidogrel treatment, an anti-platelet agent that has been associated with immunologically mediated TTP/HUS. We present a second case of TTP/HUS developing in an SPK recipient who was also receiving clopidogrel. Methods. After a stroke, a 48-year-old male SPK transplant recipient received clopidogrel. Four months later, thrombosis and rejection of the transplanted pancreas occurred. One week after a pancreatectomy, TTP/HUS developed that resolved with clopidogrel and sirolimus discontinuation and lowering of the tacrolimus dose. Results. A plasma sample revealed von Willebrand factor cleaving metalloproteinase activity, although no immunoglobulins to the protease were identified. The patient continues taking tacrolimus with normal renal function 1 year after the incident. Discussion. Our findings suggest a nonimmunological etiology for TTP/HUS in clopidogrel-treated transplant recipients. Furthermore, mechanistic focused laboratory studies can facilitate interpretation of case report findings.

Original languageEnglish (US)
Pages (from-to)885-887
Number of pages3
JournalTransplantation
Volume74
Issue number6
DOIs
StatePublished - Sep 27 2002

ASJC Scopus subject areas

  • Transplantation

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