TY - JOUR
T1 - Tubular biomarkers to assess progression of diabetic nephropathy
AU - Tramonti, Gianfranco
AU - Kanwar, Yashpal S.
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2011/5
Y1 - 2011/5
N2 - Despite aggressive management, many patients with diabetic nephropathy still develop end-stage renal disease. Accompanying tubulointerstitial damage is important in the progression of diabetic nephropathy. Markers of tubular damage, such as NGAL, KIM-1, and LFABP, have been proposed for monitoring the effectiveness of therapy. However, Nielsen et al. report a lack of an independent correlation between these biomarkers and glomerular filtration rate. Therefore, these markers seem to offer no improvement in the management of diabetic nephropathy.
AB - Despite aggressive management, many patients with diabetic nephropathy still develop end-stage renal disease. Accompanying tubulointerstitial damage is important in the progression of diabetic nephropathy. Markers of tubular damage, such as NGAL, KIM-1, and LFABP, have been proposed for monitoring the effectiveness of therapy. However, Nielsen et al. report a lack of an independent correlation between these biomarkers and glomerular filtration rate. Therefore, these markers seem to offer no improvement in the management of diabetic nephropathy.
UR - http://www.scopus.com/inward/record.url?scp=79955595112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955595112&partnerID=8YFLogxK
U2 - 10.1038/ki.2011.9
DO - 10.1038/ki.2011.9
M3 - Comment/debate
C2 - 21527942
AN - SCOPUS:79955595112
SN - 0085-2538
VL - 79
SP - 1042
EP - 1044
JO - Kidney international
JF - Kidney international
IS - 10
ER -
