Tubulo-Interstitial Nephritis Associated with Polyomavirus (BK Type) Infection

S. Rosen, W. Harmon, A. M. Krensky, P. J. Edelson, B. L. Padgett, B. W. Grinnell, M. J. Rubino, D. L. Walker

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120 Scopus citations

Abstract

We studied viral injury to the kidney in a six-year-old boy with hyperimmunoglobulin M immunodeficiency who presented with irreversible acute renal failure and eventually died after five months of dialysis. Renal biopsy at the time of his presentation revealed a predominantly tubulo-interstitial process with numerous viral inclusions that were identified as polyomavirus. Urine cultures showed a massive viruria with BK-type polyomavirus. The kidney disease was end stage, with persistence of BK virus identified by morphologic techniques and by culture. DNA hybridization analysis showed virus in low concentration in the lymph nodes, spleen, and lungs. The marked viruria, the high concentration of BK virus, and the extensive distribution of viral antigen throughout the kidney all suggest that infection with BK virus was the basis of the severe renal parenchymal injury. (N Engl J Med 1983; 308:1192–6.).

Original languageEnglish (US)
Pages (from-to)1192-1196
Number of pages5
JournalNew England Journal of Medicine
Volume308
Issue number20
DOIs
StatePublished - May 19 1983

ASJC Scopus subject areas

  • Medicine(all)

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