Tumor cell vasculogenic mimicry: From controversy to therapeutic promise

Richard E.B. Seftor, Angela R. Hess, Elisabeth A. Seftor, Dawn A. Kirschmann, Katharine M. Hardy, Naira V. Margaryan, Mary J.C. Hendrix*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

In 1999, The American Journal of Pathology published an article entitled "Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry," by Maniotis and colleagues, which ignited a spirited debate for several years and earned distinction as a citation classic. Tumor cell vasculogenic mimicry (VM) refers to the plasticity of aggressive cancer cells forming de novo vascular networks, which thereby contribute to perfusion of rapidly growing tumors, transporting fluid from leaky vessels, and/or connecting with the constitutional endothelial-lined vasculature. The tumor cells capable of VM share a plastic, transendothelial phenotype, which may be induced by hypoxia. Since VM was introduced as a novel paradigm for melanoma tumor perfusion, many studies have contributed new findings illuminating the underlying molecular pathways supporting VM in a variety of tumors, including carcinomas, sarcomas, glioblastomas, astrocytomas, and melanomas. Facilitating the functional plasticity of tumor cell VM are key proteins associated with vascular, stem cell, and hypoxia-related signaling pathways, each deserving serious consideration as potential therapeutic targets and diagnostic indicators of the aggressive, metastatic phenotype.

Original languageEnglish (US)
Pages (from-to)1115-1125
Number of pages11
JournalAmerican Journal of Pathology
Volume181
Issue number4
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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