TY - JOUR
T1 - Tumor characteristics predictive of sentinel node metastases in 105 consecutive patients with invasive lobular carcinoma
AU - Grube, Baiba J.
AU - Hansen, Nora M.
AU - Ye, Xing
AU - Giuliano, Armando E.
N1 - Funding Information:
Supported by funding from the Leslie and Susan Gonda (Goldschmied) Foundation and the Ben B. and Joyce E. Eisenberg Foundation, Los Angeles, California, the Associates for Breast and Prostate Cancer Studies, Santa Monica, California, and the Fashion Footwear Association of New York, New York.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Background: Identification of nodal metastases in invasive lobular carcinoma (ILC) is difficult. Sentinel node (SN) biopsy offers a potential advantage. This study reports the feasibility of SN identification and predictors of SN metastases for ILC. Methods: All cases of ILC undergoing sentinel lymphadenectomy between October 1991 and May 2001 were evaluated. Patients enrolled in ACOSOG Z0010/Z0011 were excluded. Presentation, surgical treatment, tumor characteristics, and prognostic factors were analyzed for statistical significance. Results: SN mapping was performed in 105 patients with 106 cases of ILC. SN identification was 97%, accuracy 100%, and positivity 50% with 45% macrometastases, 16% micrometastases, and 39% immunometastases. There are no axillary recurrences at 43.73 months. Palpable tumor, increasing tumor size, and angiolymphatic invasion are statistically significant for SN-positive status. Conclusions: SN staging for ILC is feasible and accurate. Receptor status and proliferative indices are not useful markers for metastases. However, large tumor size and presence of angiolymphatic invasion are positive predictors.
AB - Background: Identification of nodal metastases in invasive lobular carcinoma (ILC) is difficult. Sentinel node (SN) biopsy offers a potential advantage. This study reports the feasibility of SN identification and predictors of SN metastases for ILC. Methods: All cases of ILC undergoing sentinel lymphadenectomy between October 1991 and May 2001 were evaluated. Patients enrolled in ACOSOG Z0010/Z0011 were excluded. Presentation, surgical treatment, tumor characteristics, and prognostic factors were analyzed for statistical significance. Results: SN mapping was performed in 105 patients with 106 cases of ILC. SN identification was 97%, accuracy 100%, and positivity 50% with 45% macrometastases, 16% micrometastases, and 39% immunometastases. There are no axillary recurrences at 43.73 months. Palpable tumor, increasing tumor size, and angiolymphatic invasion are statistically significant for SN-positive status. Conclusions: SN staging for ILC is feasible and accurate. Receptor status and proliferative indices are not useful markers for metastases. However, large tumor size and presence of angiolymphatic invasion are positive predictors.
KW - Breast cancer
KW - Invasive lobular carcinoma
KW - Sentinel node biopsy
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U2 - 10.1016/S0002-9610(02)00939-X
DO - 10.1016/S0002-9610(02)00939-X
M3 - Article
C2 - 12383906
AN - SCOPUS:0036805727
SN - 0002-9610
VL - 184
SP - 372
EP - 376
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 4
ER -
