Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

Keyphrases

• Tumor Cells 100%
• Cancer Cells 100%
• Tumor Heterogeneity 100%
• IFN Signaling 100%
• Immune Selection 100%
• Janus Kinase 1 (JAK1) 66%
• Melanoma Cells 33%
• Tumor 33%
• PD-L1 Expression 33%
• Selective Pressure 33%
• Drug-resistant Tumor 33%
• PD-1 Blockade 33%
• Tumor Immunity 33%
• CD8+ T Cells 33%
• CRISPR Interference (CRISPRi) 33%
• Antitumor Efficacy 33%
• Tumor Regression 33%
• T-cell Mediated 33%
• Immunotherapy Resistance 33%
• PD-1 Resistance 33%
• Clinical Reports 33%
• Tumor Clone 33%
• Pressure Control 33%
• Secondary Resistance 33%
• PD-L1 Downregulation 33%

Biochemistry, Genetics and Molecular Biology

• Cooperation 100%
• PD-L1 100%
• Cancer Cell 100%
• Wild Type 66%
• T Cell 66%
• Drive 33%
• Tumor Immunity 33%
• CRISPR 33%
• Upregulation 33%
• CD8 33%

Immunology and Microbiology

• Programmed Death-Ligand 1 100%
• Tumor Cell 100%
• Cancer Cell 100%
• Wild Type 66%
• Cytotoxic T-Cell 33%
• Tumor Immunity 33%
• Clustered Regularly Interspaced Short Palindromic Repeat 33%
• Upregulation 33%
• Melanoma Cell 33%
• Immunotherapy 33%
• T Cell 33%