Tumor-infiltrating lymphocytes and colorectal cancer survival in Africa Namerican and Caucasian Patients

Kristin Wallace*, David N. Lewin, Shaoli Sun, Clayton M. Spiceland, Don C. Rockey, Alexander V. Alekseyenko, Jennifer D. Wu, John A. Baron, Anthony J. Alberg, Elizabeth G. Hill

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Compared with Caucasian Americans (CAs), African Americans (AAs) with colorectal cancer have poorer survival, especially younger-age patients. A robust lymphocytic reaction within colorectal cancers is strongly associated with better survival, but whether immune response impacts the disparity in colorectal cancer survival is unknown. Methods: The study population was comprised of 211 histologically confirmed colorectal cancers at the Medical University of South Carolina (Charleston, SC; 159 CAs and 52 AAs) diagnosed between Jan 01, 2000, and June 30, 2013. We constructed a lymphocyte score based on blinded pathologic assessment of the four different types of lymphocytic reactions. Cox proportional hazards regression was used to evaluate the association between the lymphocyte score and risk of death by race. Results: Colorectal cancers in AAs (vs. CAs) had a stronger lymphocytic reaction at diagnosis. A high lymphocyte score (vs. the lowest) was associated with better survival in AAs [HR 0.19; 95% confidence interval (CI), 0.04-0.99] and CAs (HR 0.47; 95% CI, 0.15-1.45). AAs with no lymphocytic reaction (vs. other categories) had poor survival HR 4.48 (1.58-12.7) whereas no difference was observed in CAs. The risk of death in AAs (vs. CA) was more pronounced in younger patients (HR 2.92; 95% CI, 1.18-7.22) compared with older (HR 1.20; 95% CI, 0.54-2.67), especially those with lymphocytic poor colorectal cancers. Conclusions: The lymphocytic reaction in tumor impacted the racial disparity in survival. Impact: Our results confirm the importance of the lymphocytic score on survival and highlight the need to fully characterize the immune environment of colorectal cancers by race.

Original languageEnglish (US)
Pages (from-to)755-761
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume27
Issue number7
DOIs
StatePublished - Jul 2018

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'Tumor-infiltrating lymphocytes and colorectal cancer survival in Africa Namerican and Caucasian Patients'. Together they form a unique fingerprint.

  • Cite this

    Wallace, K., Lewin, D. N., Sun, S., Spiceland, C. M., Rockey, D. C., Alekseyenko, A. V., Wu, J. D., Baron, J. A., Alberg, A. J., & Hill, E. G. (2018). Tumor-infiltrating lymphocytes and colorectal cancer survival in Africa Namerican and Caucasian Patients. Cancer Epidemiology Biomarkers and Prevention, 27(7), 755-761. https://doi.org/10.1158/1055-9965.EPI-17-0870