Tumor lysis syndrome: Risk factors, diagnosis, and management

Rebekah A. Burns, Irina Topoz*, Sally L. Reynolds

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Tumor lysis syndrome (TLS) is a potentially fatal complication of induction therapy for several types of malignancies. Electrolyte derangements and even downstream complications may also occur prior to the initial presentation to a medical provider, before an oncologic diagnosis has been established. It is therefore imperative that emergency physicians be familiar with the risk factors for TLS in children as well as the criteria for diagnosis and the strategies for prevention and management. Careful evaluation of serum electrolytes, uric acid, and renal function must occur. Patients at risk for TLS and those who already exhibit laboratory or clinical evidence of TLS require close monitoring, aggressive hydration, and appropriate medical treatment.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalPediatric emergency care
Issue number8
StatePublished - Aug 2014


  • allopurinol
  • hyperuricemia
  • oncologic emergencies
  • rasburicase
  • tumor lysis syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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