Tumor Microenvironment and Hemorheological Abnormalities

Gianfranco Baronzio; Isabel Freitas; Hau C. Kwaan

doi:10.1055/s-2003-44557

Tumor Microenvironment and Hemorheological Abnormalities

Gianfranco Baronzio, Isabel Freitas^*, Hau C. Kwaan

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

Original language	English (US)
Pages (from-to)	489-497
Number of pages	9
Journal	Seminars in thrombosis and hemostasis
Volume	29
Issue number	5
DOIs	https://doi.org/10.1055/s-2003-44557
State	Published - Oct 2003

Keywords

Hemorheology
Hypoxia
Thrombosis
Tumor interstitial fluid
VEGF

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

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title = "Tumor Microenvironment and Hemorheological Abnormalities",

abstract = "This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.",

keywords = "Hemorheology, Hypoxia, Thrombosis, Tumor interstitial fluid, VEGF",

author = "Gianfranco Baronzio and Isabel Freitas and Kwaan, {Hau C.}",

year = "2003",

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T1 - Tumor Microenvironment and Hemorheological Abnormalities

AU - Baronzio, Gianfranco

AU - Freitas, Isabel

AU - Kwaan, Hau C.

PY - 2003/10

Y1 - 2003/10

N2 - This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

AB - This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

KW - Hemorheology

KW - Hypoxia

KW - Thrombosis

KW - Tumor interstitial fluid

KW - VEGF

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M3 - Review article

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AN - SCOPUS:0242298635

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JF - Seminars in thrombosis and hemostasis

IS - 5

ER -

Tumor Microenvironment and Hemorheological Abnormalities

Abstract

Keywords

ASJC Scopus subject areas

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