Tumor necrosis factor-α is decreased in the umbilical cord plasma of patients with severe preeclampsia

Michael J. Kupferminc*, Alan M. Peaceman, Shaul Dollberg, Michael L. Socol

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations


We investigated the role of the fetal immune system in pregnancies complicated by preeclampsia by assessing umbilical cord plasma levels of the cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Nineteen nulliparous patients with severe preeclampsia composed the study group (group A). A comparison group was comprised of 19 healthy nulliparous patients with uneventful pregnancies (group B). Mixed umbilical cord blood was collected immediately after delivery. Plasma was prepared and all samples were assayed for TNF-α and IL-1β by specific enzyme-linked immunoassays (ELISAs). Data are presented as the median with range of values. The length of labor was similar in both groups. TNF-α was detected less frequently in the umbilical cord plasma of preeclamptic patients than in the umbilical cord plasma of control patients (57.9 vs. 89.5%, p < 0.05), and the concentrations of TNF-α were significantly lower in the umbilical cord plasma of the preeclamptic patients [20 pg/ml (0-80 pg/mL) vs. 50 pg/mL (0-310 pg/mL), p < 0.05]. Umbilical cord plasma IL-1β detection rates and concentrations from the preeclamptic and control patients were similar, [15.8 vs. 5.3%, 0 pg/mL (0-40 pg/mL) vs 0 pg/mL (0-10 pg/mL)]. The lower concentrations of TNF-α in umbilical cord plasma of patients with severe preeclampsia suggest that release of TNF-α by the fetus and mother are independent and may reflect adaptation of the fetus to reduced placental perfusion in preeclampsia.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalAmerican Journal of Perinatology
Issue number5
StatePublished - Jan 1 1999



  • Cytokines
  • Preeclampsia
  • TNF-α
  • Umbilical cord

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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